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Saizen

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What is SAIZEN® (somatropin) for injection?

Saizen is a prescription medicine that is used to treat growth hormone deficiency (GHD) in:

1- Children with growth failure who produce low amounts of growth hormone.
2- Adults with GHD that started as a
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SAIZEN 8MG (24IU) CLICK EASY - MERCK

Formula: C99H1529N2630O299S7
 

Human Growth hormone (HGH), also known as somatotropin or somatropin, is a peptide hormone that stimulates growth, cell reproduction and regeneration in humans and other animals. It is a type of mitogen which is specific only to certain kinds of cells. Growth hormone is a 191-amino acid, single-chain polypeptide that is synthesized, stored, and secreted by somatotropic cells within the lateral wings of the anterior pituitary gland. Many factors influence the release of Human Growth Hormone, however, including nutrition and exercise. 

Human Growth Hormone stimulates the body cells to increase both in size, as well as undergo more rapid cell division than usual. In addition, it enhances the movement of amino acids through cell membranes and also increases the rate at which these cells convert these molecules into proteins. Clearly, you can see that this would amount to an anabolic (muscle building) effect in the human body. Human Growth Hormone also has the ability to cause cells to decrease the normal rate at which they utilize carbohydrates, and simultaneously increase the rate at which they use fats. Fat loss and lean mass increases with Human Growth Hormone have been found at a dose as low as 0.028 iu/kg/daily for 24 weeks. It also stimulates production of IGF-1.

HGH is used in medicine to treat children's growth disorders and adult growth hormone deficiency. Studies reliably demonstrate that the following are among the beneficial effects of modulating HGH:

  • Enhanced skin thickness and elasticity
  • Improved healing time and reduced infection rates after trauma or surger, it Increases protein synthesis
  • Diminished sun damage-type wrinkling
  • Decreased total body fat, it promotes lipolysis
  • Increased lean muscle mass
  • Increased bone mineral density; it increases calcium retention, and strengthens the mineralization of bone
  • Improved cholesterol profile 
  • Decreased LDL (bad) cholesterol
  • Increased HDL (good) cholesterol
  • Improved exercise capacity
  • Decreased recovery time between workouts
  • Improved blood flow to the kidney
  • Improved mood, coping skills, and over-all well-being
  • It contributes to the strengthening of the joints and ligaments in the body
  • Plays a role in homeostasis
  • Reduces liver uptake of glucose
  • Promotes gluconeogenesis in the liver
  • Contributes to the maintenance and function of pancreatic islets
  • Stimulates the immune system
  • Increases deiodination of T4 to T3

 

Also several studies, primarily involving patients with HGH deficiency, have suggested a crucial role of HGH in both mental and emotional well-being and maintaining a high energy level. Adults with HGH deficiency often have higher rates of depression than those without.

HGH has also been studied in the context of cognitive function, including learning and memory. HGH in humans appears to induce cognitive function and may be useful in the treatment of patients with cognitive impairment that is a result of HGH deficiency

In its role as an anabolic agent, HGH has been abused by competitors in sports at least since 1982. HGH can easily produce very nice, high quality weight and muscle gains, it’s a very poor compound for inducing strength gains. Competitors of the '70s, and especially the '80s began to present a more refined look with chiseled muscle development reminiscent of Classical Sculpture and resembling deeply etched rock. Those guys, one could reasonably postulate, were not adding additional cardio to their programs and eating more lean proteins.

HGH shows much more effect and positive qualities in stack with a steroid cycle as alone. So, this compound is generally suitable for cutting cycles to get lean muscles and burn fat.


 

What does Saizen®(somatropin) for injection do?

Saizen® (somatropin) for injection steps in when the body doesn’t produce enough growth hormone on its own. Saizen® is a human growth hormone produced by recombinant DNA technology. It is a type of treatment called growth hormone replacement therapy and is available by prescription only. The structure of the growth hormone used in treatment is identical to the growth hormone produced by the pituitary gland.

Saizen® is used for growth hormone therapy to replace the hormone that the body fails to produce on its own. It works to stimulate skeletal growth, increase the number and size of skeletal muscle cells, influence the size and function of internal organs, and has important effects on metabolism.

Treatment may not only help a body grow in height, but will also play an important role in stimulating the liver and other tissues to secrete IGF-1, a protein which supports muscle growth and metabolic functions.

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Indication

What is SAIZEN® (somatropin) for injection?

Saizen is a prescription medicine that is used to treat growth hormone deficiency (GHD) in:

1- Children with growth failure who produce low amounts of growth hormone.
2- Adults with GHD that started as a child or as an adult.

Saizen is an injectable form of a protein called growth hormone that is produced by your body.

Important Risk Information

Who should not take SAIZEN?

Saizen should not be used in children after the growth plates have closed.

Saizen should not be used in children and adults with any of the following medical conditions because serious side effects can occur:

  • A critical illness from surgery, serious injuries, or a severe breathing problem
  • Prader-Willi syndrome who are severely overweight or have a history of breathing
    problems including sleep apnea
  • Cancer or other tumors
  • Allergies to growth hormone
  • Eye problems caused by diabetes

What should patients tell their doctor before taking SAIZEN?

  • If you have or had cancer as a child. There is an increased risk of getting another tumor if you are a childhood cancer survivor
  • If you have diabetes, are at risk for getting diabetes, or have blood sugar levels that are higher than normal. New cases of type 2 diabetes have been reported in patients taking Saizen
  • If you are allergic to growth hormone, or other ingredients such as benzyl alcohol, sucrose, phosphoric acid, sodium hydroxide, or metacresol
  • If you are taking any other medicines (both prescription or over the counter), vitamins, or supplements because these medicines may affect each other. Your doctor may need to adjust the dose of Saizen or other medicines you are taking
  • If you are nursing, pregnant, or plan to become pregnant. It is not known if Saizen passes into your breast milk or could harm your unborn baby

Your doctor will perform certain tests before prescribing SAIZEN and will monitor progress during the course of treatment.

What are the most common side effects of SAIZEN reported in clinical trials in patients treated for GHD?

The most common side effects reported are:

  • An injection site reaction such as pain, numbness, redness, and swelling
  • Muscle and joint pain
  • Tingling and numbness
  • Unusual skin sensations
  • Headache
  • Adults also commonly report swelling associated with fluid retention especially in the legs, arms, and face

Other less common but serious side effects of SAIZEN are:

  • High blood sugar (hyperglycemia/diabetes) which can include symptoms of increased thirst and urination, tiredness, trouble concentrating and weight loss
  • Headaches, changes in vision, nausea or vomiting which requires immediate medical attention
  • Serious allergic reactions that require immediate medical attention.
  • Hip and knee pain or a limp in children, which can be a sign that the thigh bone and hip joint may have slipped out of place
  • Curvature of the spine or backbone in children (scoliosis)
  • Pain and tenderness in the abdomen, which could be a sign of a problem with the pancreas

These are not all of the possible side effects. Let your doctor know about any side effects you may experience.

How should you administer SAIZEN?

Patients and caregivers should be trained by a healthcare professional on how to mix and inject Saizen prior to use. Children should always be supervised.

You may report side effects to EMD Serono at 1-800-283-8088 ext 5563. You may also report side effects to the FDA at 1-800-FDA-1088 or http://www.fda.gov/medwatch.

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